Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24729172 | 1.00 | MGAM (0.44) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL7859854 | 0.79 | SLC6A4 (0.54) | MGAMGAASIMGAM2PIM1 | |
| SCHEMBL25318965 | 0.76 | MGAM (0.45) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL30344459 | 0.74 | CYP2D6 (0.48) | MGAMGAASIMGAM2PIM1 | |
| Hydrochloric Acid SCHEMBL11221310 | 0.73 | CYP2D6 (0.51) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL11226658 | 0.71 | DRD3 (0.46) | KDM4EATMTP53MAPT | |
| SCHEMBL29651185 | 0.70 | MGAM (0.35) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL22864438 | 0.70 | MGAM (0.35) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL22750609 | 0.70 | SLC6A3 (0.41) | GAAKDM4ECYP2D6SLC6A2SLC6A4 | |
| SCHEMBL22864444 | 0.70 | ATM (0.48) | MGAMGAASIMGAM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555585-B | HPK1 inhibitors and uses thereof | 锐格药业公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |
| EP-3994133-A1 | HPK1 INHIBITORS AND USES THEREOF | Qilu Regor Therapeutics Inc. (CN) | 2022-05-11 | — | — | EP | disclosed |