Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 5/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21835735 | 1.00 | DGAT1 (0.41) | DGAT1L3MBTL1MAPTMAPK1TDP1 | |
| SCHEMBL29652976 | 0.87 | UCHL1 (0.41) | DGAT1NPC1 | |
| SCHEMBL24456583 | 0.87 | UCHL1 (0.41) | DGAT1NPC1 | |
| SCHEMBL30746198 | 0.86 | EGFR (0.42) | DGAT1MAPK1MRGPRX4HTTSMN1; SMN2 | |
| SCHEMBL27262838 | 0.86 | EGFR (0.42) | DGAT1MAPK1MRGPRX4HTTSMN1; SMN2 | |
| SCHEMBL29652912 | 0.85 | DGAT1 (0.40) | DGAT1L3MBTL1MAPTMAPK1TDP1 | |
| SCHEMBL17258894 | 0.85 | DGAT1 (0.40) | DGAT1L3MBTL1MAPTMAPK1TDP1 | |
| SCHEMBL21835741 | 0.85 | MRGPRX4 (0.45) | DGAT1L3MBTL1MAPTMAPK1TDP1 | |
| SCHEMBL30809615 | 0.85 | MRGPRX4 (0.45) | DGAT1L3MBTL1MAPTMAPK1TDP1 | |
| SCHEMBL25723319 | 0.85 | CHRNA7 (0.42) | DGAT1L3MBTL1MAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |