Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17258894 | 1.00 | DGAT1 (0.40) | DGAT1S1PR5L3MBTL1MAPK14BRD4 | |
| SCHEMBL17258921 | 0.87 | DGAT1 (0.38) | DGAT1S1PR5L3MBTL1MAPK14BRD4 | |
| SCHEMBL31495927 | 0.86 | DGAT1 (0.38) | DGAT1S1PR5L3MBTL1BRD4MRGPRX4 | |
| SCHEMBL27090098 | 0.86 | DGAT1 (0.40) | DGAT1S1PR5L3MBTL1MAPK14BRD4 | |
| SCHEMBL21835735 | 0.85 | DGAT1 (0.41) | DGAT1S1PR5L3MBTL1BRD4MRGPRX4 | |
| SCHEMBL29653247 | 0.85 | DGAT1 (0.41) | DGAT1S1PR5L3MBTL1BRD4MRGPRX4 | |
| SCHEMBL27262838 | 0.84 | EGFR (0.42) | DGAT1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL30746198 | 0.84 | EGFR (0.42) | DGAT1MRGPRX4NPC1CTSVCTSL | |
| SCHEMBL23367881 | 0.80 | ROCK1 (0.38) | DGAT1 | |
| SCHEMBL18819293 | 0.80 | LPL (0.34) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359402-A1 | IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-110573157-B | Methods of treatment using JAK inhibitor compounds | 施万生物制药研发IP有限责任公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-110603255-B | Crystalline forms of a JAK inhibitor compound | 施万生物制药研发IP有限责任公司 | 2023-02-10 | — | — | CN | disclosed |
| EP-4114836-A1 | CRYSTALLINE HYDRATE OF A JAK INHIBITOR COMPOUND | Theravance Biopharma R&D IP, LLC (US) | 2023-01-11 | — | — | EP | disclosed |
| WO-2022272020-A1 | IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2022-12-29 | — | — | WO | disclosed |
| CN-110461839-B | JAK inhibitors containing 4-membered heterocyclic amides | 施万生物制药研发IP有限责任公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-110382498-B | Fused imidazole-piperidine JAK inhibitors | 施万生物制药研发IP有限责任公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-110573508-B | Fused imidazo-piperidine JAK inhibitor compounds | 施万生物制药研发IP有限责任公司 | 2022-07-05 | — | — | CN | disclosed |
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |