Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.36 |
| ▸ | LPL | P06858 | 2/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24456142 | 1.00 | ENPP2 (0.45) | ENPP2HSD17B10S1PR1LPLLIPG | |
| SCHEMBL29653353 | 0.83 | ENPP2 (0.45) | ENPP2HSD17B10S1PR1LPLLIPG | |
| SCHEMBL6487851 | 0.83 | ENPP2 (0.45) | ENPP2HSD17B10S1PR1LPLLIPG | |
| SCHEMBL16635109 | 0.81 | F11 (0.47) | ENPP2LPLLIPG | |
| SCHEMBL3791071 | 0.78 | ENPP2 (0.45) | ENPP2HSD17B10LPLLIPGPRSS1 | |
| SCHEMBL16576673 | 0.78 | ESR1 (0.45) | HSD17B10LPLLIPGESR1ESR2 | |
| SCHEMBL3786642 | 0.77 | ENPP2 (0.44) | ENPP2HSD17B10LPLLIPGPRSS1 | |
| SCHEMBL29955406 | 0.77 | ENPP2 (0.44) | ENPP2HSD17B10S1PR1LPLLIPG | |
| SCHEMBL7962703 | 0.77 | CYP4F2 (0.47) | ENPP2HSD17B10LPLLIPGPRSS1 | |
| SCHEMBL29954459 | 0.77 | CYP4F2 (0.47) | ENPP2HSD17B10LPLLIPGPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |