Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539997 | 1.00 | KDM4E (0.44) | KDM4EHSD17B10NPC1ALDH1A1TTR | |
| SCHEMBL29476287 | 0.88 | ALPL (0.41) | KDM4ENPC1ALDH1A1LMNAGAA | |
| SCHEMBL23539711 | 0.88 | ALPL (0.41) | KDM4ENPC1ALDH1A1LMNAGAA | |
| SCHEMBL23539879 | 0.85 | KDM4E (0.46) | KDM4EHSD17B10NPC1MEN1KMT2A | |
| SCHEMBL25326637 | 0.78 | CFTR (0.52) | KDM4EHSD17B10ALDH1A1TTRMEN1 | |
| SCHEMBL252578 | 0.74 | KDM4E (0.65) | KDM4EHSD17B10NPC1ALDH1A1LMNA | |
| SCHEMBL7144739 | 0.74 | KDM4E (0.51) | KDM4EHSD17B10NPC1ALDH1A1MEN1 | |
| SCHEMBL23541000 | 0.73 | SLC6A4 (0.49) | KDM4EHSD17B10NPC1ALDH1A1LMNA | |
| SCHEMBL29476278 | 0.73 | SLC6A4 (0.49) | KDM4EHSD17B10NPC1ALDH1A1LMNA | |
| SCHEMBL30603334 | 0.72 | SMN1; SMN2 (0.46) | KDM4ENPC1ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133345-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-06-23 | — | — | WO | disclosed |