Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539711 | 1.00 | ALPL (0.41) | ALPLCFTRSMN1; SMN2LMNARAB9A | |
| SCHEMBL29654688 | 0.88 | KDM4E (0.44) | SMN1; SMN2LMNAMAPTNPC1KDM4E | |
| SCHEMBL23539997 | 0.88 | KDM4E (0.44) | SMN1; SMN2LMNAMAPTNPC1KDM4E | |
| SCHEMBL29476278 | 0.86 | SLC6A4 (0.49) | CFTRSMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL23541000 | 0.86 | SLC6A4 (0.49) | CFTRSMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL25484858 | 0.84 | ALPL (0.43) | ALPLSMN1; SMN2LMNARAB9AMAPT | |
| SCHEMBL23539577 | 0.83 | ALPL (0.43) | ALPLCFTRSMN1; SMN2LMNARAB9A | |
| SCHEMBL29476206 | 0.83 | ALDH1A1 (0.40) | ALPLCFTRRAB9AMAPTNPC1 | |
| SCHEMBL23539849 | 0.83 | ALDH1A1 (0.40) | ALPLCFTRRAB9AMAPTNPC1 | |
| SCHEMBL23539751 | 0.82 | CFTR (0.56) | ALPLCFTRMAPTKDM4EPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217071-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-4076667-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2022133345-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022066805-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-03-31 | — | — | WO | disclosed |