Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721310 | 1.00 | TDP1 (0.71) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL720358 | 0.85 | TDP1 (0.79) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL28045348 | 0.85 | TDP1 (0.52) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL737722 | 0.84 | MAPT (1.00) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL29409289 | 0.84 | MAPT (1.00) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL6313832 | 0.83 | ALDH1A1 (0.53) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL653911 | 0.83 | TDP1 (0.81) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL30255693 | 0.83 | TDP1 (0.81) | TDP1MAPTMEN1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL3973012 | 0.81 | MAPT (0.92) | TDP1MAPTMEN1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL3973011 | 0.81 | MAPT (0.92) | TDP1MAPTMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843874-B | Phthalazine derivatives useful as inhibitors of PARP1, PARP2 and/or tubulin for the treatment of cancer | 加利福尼亚大学董事会 | 2022-05-27 | — | — | CN | disclosed |