Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.43 |
| ▸ | FEN1 | P39748 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655044 | 0.82 | MAPT (0.50) | ARADRB2MAPK1RAB9AKDM4E | |
| SCHEMBL29655117 | 0.80 | PTPRC (0.56) | ARALOX5APFEN1HTR7PTPRC | |
| SCHEMBL29655234 | 0.80 | PTPRC (0.56) | ARALOX5APFEN1HTR7PTPRC | |
| SCHEMBL5953394 | 0.80 | PTPRC (0.56) | ARALOX5APFEN1HTR7PTPRC | |
| SCHEMBL10528636 | 0.79 | ADRB2 (0.73) | ADRB2TP53MAPK1RAB9AKDM4E | |
| SCHEMBL478309 | 0.78 | HTR7 (0.56) | ARADRB2TP53MAPK1RAB9A | |
| SCHEMBL2572079 | 0.77 | ADRB2 (0.54) | ARADRB2TP53MAPK1RAB9A | |
| SCHEMBL9073879 | 0.75 | ALDH1A1 (0.63) | ARTP53MAPK1KDM4EL3MBTL1 | |
| SCHEMBL29684634 | 0.75 | CYP1A2 (0.66) | ADRB2TP53KDM4EL3MBTL1GAA | |
| SCHEMBL1029928 | 0.75 | CYP1A2 (0.66) | ADRB2TP53KDM4EL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843874-B | Phthalazine derivatives useful as inhibitors of PARP1, PARP2 and/or tubulin for the treatment of cancer | 加利福尼亚大学董事会 | 2022-05-27 | — | — | CN | disclosed |