Sugi Predict

Sugi Predict / Compounds / SCHEMBL29655430

SCHEMBL29655430

SCHEMBL29655430

CC(C)(C)OC(=O)Nc1c(F)cc(F)cc1C#C[Si](C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 1/20 0.36
▸ ATR Q13535 1/20 0.35
▸ CYP17A1 P05093 1/20 0.34
▸ EGLN2 Q96KS0 2/20 0.34
▸ KCNQ4 P56696 3/20 0.33
▸ KCNQ5 Q9NR82 3/20 0.33
▸ TRPA1 O75762 1/20 0.33
▸ LCK P06239 3/20 0.32
▸ GABRA1 P14867 1/20 0.32
▸ GABRG2 P18507 1/20 0.32
▸ GABRB3 P28472 1/20 0.32
▸ GABRA5 P31644 1/20 0.32
▸ GABRA3 P34903 1/20 0.32
▸ GABRA2 P47869 1/20 0.32
▸ GABRA6 Q16445 1/20 0.32
▸ CA12 O43570 1/20 0.32
▸ CA1 P00915 1/20 0.32
▸ CA9 Q16790 1/20 0.32
▸ PSMB8 P28062 1/20 0.32
▸ HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20541986 1.00 SYK (0.36) SYKATRCYP17A1EGLN2KCNQ4
SCHEMBL29016666 0.87 HTT (0.34) HTT
SCHEMBL8670078 0.84 HTT (0.35) SYKHTT
SCHEMBL5645474 0.82 RAB9A (0.41) KCNQ4KCNQ5HTT
SCHEMBL20541829 0.81 HTT (0.38) HTT
SCHEMBL6578598 0.74 HDAC1 (0.38) SYKATRCYP17A1KCNQ4KCNQ5
SCHEMBL8280454 0.74 ALDH1A1 (0.49) ATRCA12CA1CA9HTT
SCHEMBL30418571 0.73 CYP17A1 (0.38) SYKATRCYP17A1KCNQ4KCNQ5
SCHEMBL26426334 0.73 CYP17A1 (0.38) SYKATRCYP17A1KCNQ4KCNQ5
SCHEMBL23147977 0.72 CYP17A1 (0.39) SYKATRCYP17A1KCNQ4KCNQ5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4710923-A2 INDOLE AHR INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2026-03-18 — — EP disclosed
EP-3612030-B1 INDOLE AHR INHIBITORS AND USES THEREOF IKENA ONCOLOGY INC (US) 2025-12-24 — — EP disclosed
US-20250122205-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2025-04-17 — — US disclosed
US-12077542-B2 Indole AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2024-09-03 — — US disclosed
US-20230028336-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2023-01-26 — — US disclosed
US-11358969-B2 Indole AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2022-06-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11358969-B2 Indole AHR inhibitors and uses thereof AHR, ARNT, IDO1 SYK 3203/4885ATR 3082/4885CYP17A1 104/4885
US-20250122205-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 SYK 3203/4885ATR 3082/4885CYP17A1 104/4885
US-20230028336-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 SYK 3203/4885ATR 3082/4885CYP17A1 104/4885
US-12077542-B2 Indole AHR inhibitors and uses thereof AHR, ARNT, IDO1 SYK 3203/4885ATR 3082/4885CYP17A1 104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.