Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aristolic Acid SCHEMBL29655686 | 0.77 | ALDH1A1 (0.67) | CDK2ALDH1A1MEN1KMT2AMAPT | |
| Aristolic Acid SCHEMBL9871957 | 0.77 | ALDH1A1 (0.67) | CDK2ALDH1A1MEN1KMT2AMAPT | |
| Aristolamide SCHEMBL31261987 | 0.76 | MEN1 (0.58) | CDK2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL32690182 | 0.71 | ALDH1A1 (0.68) | CDK2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2987592 | 0.69 | IMPDH2 (0.79) | ALDH1A1MAPTSMN1; SMN2IMPDH2IMPDH1 | |
| Aristolactam I SCHEMBL29440224 | 0.68 | CDK2 (1.00) | CDK2ALDH1A1MEN1KMT2AMAPT | |
| Aristolactam I SCHEMBL29104188 | 0.68 | CDK2 (1.00) | CDK2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1145699 | 0.66 | ALDH1A1 (0.47) | CDK2ALDH1A1CYP3A4SMN1; SMN2HTR2A | |
| SCHEMBL523983 | 0.66 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AMAPTCYP3A4 | |
| SCHEMBL1344283 | 0.66 | CYP3A4 (0.53) | ALDH1A1MEN1KMT2ACYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5024743-A | Prophylaxis and therapy of infectious diseases | MADAUS GMBH & CO. (DE) | 1991-06-18 | — | — | US | disclosed |
| US-4835178-A | Methylendioxyphenathrene and stilben derivatives, process for the preparation thereof, pharmaceutical compositions using these, and therapeutic applications | DR. MADAUS & CO. (DE) | 1989-05-30 | — | — | US | disclosed |