Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17563223 | 0.88 | SLC1A3 (0.50) | IKBKBBRD4MAOBMAPTCNR2 | |
| SCHEMBL16127491 | 0.84 | IKBKB (0.53) | IKBKBBRD4MAOBMAPTCNR2 | |
| SCHEMBL31711762 | 0.81 | HSD17B1 (0.33) | TAAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16127352 | 0.79 | IKBKB (0.49) | IKBKBBRD4MAPTCNR2SLC1A3 | |
| SCHEMBL29678302 | 0.79 | TSHR (0.58) | MAOBTSHRMAPK1IDO1NOTUM | |
| SCHEMBL1263144 | 0.79 | TSHR (0.58) | MAOBTSHRMAPK1IDO1NOTUM | |
| SCHEMBL4934915 | 0.78 | TSHR (0.45) | MAOBMAPTTSHRMAPK1IDO1 | |
| SCHEMBL16127490 | 0.78 | IDO1 (0.53) | IKBKBBRD4MAOBMAPTIDO1 | |
| SCHEMBL28248236 | 0.78 | KIF11 (0.46) | MAOBAKR1C3AKR1C2TSHRTAAR1 | |
| Ammonia Solution, Strong SCHEMBL20472961 | 0.77 | MAOB (0.56) | MAOBTSHRMAPK1IDO1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240034730-A1 | PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS | DRUG DISCOVERY AND CLINIC S.R.L. (IT) | 2024-02-01 | — | — | US | disclosed |
| CN-117042775-A | Pyrazolo derivatives as inhibitors of human dihydroorotate dehydrogenase (HDHODH) as antiviral agents | 药物研发和临床有限责任公司 | 2023-11-10 | — | — | CN | disclosed |
| EP-4243818-A1 | PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS | Drug Discovery and Clinic S.r.l. (IT) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022101382-A1 | PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS | DRUG DISCOVERY AND CLINIC S.R.L. (IT) | 2022-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240034730-A1 | PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS | DHODH, DPYD, IMPDH1 | IKBKB 1110/4885BRD4 1631/4885MAOB 495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.