Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376253 | 0.86 | MRGPRX4 (0.39) | MRGPRX4HIF1AMAPTTP53MEN1 | |
| SCHEMBL2965712 | 0.84 | BCL2L1 (0.46) | BCL2L1BCL2HIF1AMAPTTP53 | |
| SCHEMBL4639085 | 0.82 | GAA (0.41) | TP53MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL376911 | 0.79 | PARP14 (0.45) | BCL2L1BCL2HIF1AMAPTTP53 | |
| SCHEMBL376530 | 0.78 | ALDH1A1 (0.44) | BCL2L1BCL2MAPTTP53MEN1 | |
| SCHEMBL13503798 | 0.76 | ALDH1A1 (0.42) | BCL2L1BCL2MAPTMEN1KMT2A | |
| SCHEMBL386110 | 0.75 | F2 (0.47) | BCL2L1BCL2MAPTMEN1KMT2A | |
| SCHEMBL2962385 | 0.74 | KMT2A (0.38) | BCL2L1BCL2MAPTTP53MEN1 | |
| SCHEMBL376891 | 0.74 | KDM4E (0.45) | BCL2L1BCL2MAPTTP53MEN1 | |
| SCHEMBL28804991 | 0.71 | IP6K1 (0.56) | MRGPRX4HIF1AMAPTTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765778-B1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2012-01-25 | — | — | EP | disclosed |