Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396 | 1.00 | POLB (0.61) | POLBALDH1A1CYP2D6GFERPKM | |
| SCHEMBL12090207 | 0.78 | POLB (0.69) | POLBALDH1A1CYP2D6PKMCHRM1 | |
| SCHEMBL23089669 | 0.77 | POLB (0.90) | POLBALDH1A1CYP2D6PKMCHRM1 | |
| SCHEMBL2977562 | 0.77 | POLB (0.97) | POLBALDH1A1CYP2D6PKMLMNA | |
| SCHEMBL3225812 | 0.77 | PKM (0.66) | POLBGFERPKMRAB9AGLA | |
| SCHEMBL24058211 | 0.77 | POLB (0.56) | POLBALDH1A1CYP2D6PKMCHRM1 | |
| SCHEMBL3633802 | 0.77 | POLB (0.72) | POLBALDH1A1CYP2D6PKMCHRM1 | |
| SCHEMBL14134639 | 0.76 | POLB (1.00) | POLBALDH1A1CYP2D6PKMLMNA | |
| SCHEMBL3915047 | 0.75 | GLA (0.78) | ALDH1A1GFERPKMRAB9AGLA | |
| SCHEMBL3928664 | 0.75 | GFER (0.69) | POLBALDH1A1GFERPKMGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621189-B | Lactam derivative and application thereof | 上海拓界生物医药科技有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-114621189-A | Lactam derivative and application thereof | 上海拓界生物医药科技有限公司 | 2022-06-14 | — | — | CN | disclosed |