Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.36 |
| ▸ | HPGD | P15428 | 7/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 4/20 | 0.32 |
| ▸ | PRKCH | P24723 | 2/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19734683 | 1.00 | KDM4E (0.36) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL29658504 | 0.86 | KDM4E (0.36) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL19716407 | 0.86 | KDM4E (0.36) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL19734698 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL19734832 | 0.77 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL19734688 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL19716748 | 0.76 | DNMT1 (0.36) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL19717597 | 0.74 | DNMT1 (0.38) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL19734994 | 0.72 | DNMT1 (0.53) | KDM4EALDH1A1HPGDPOLBGAA | |
| SCHEMBL19716665 | 0.72 | DNMT1 (0.70) | DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563043-B | Substituted pyridines as inhibitors of DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2022-05-31 | — | — | CN | disclosed |