Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19716478 | 1.00 | MAPT (0.40) | MAPTGAAKDM4EALDH1A1HPGD | |
| SCHEMBL19734742 | 0.88 | MAPT (0.37) | MAPTGAAKDM4EALDH1A1HPGD | |
| Ammonia Solution, Strong SCHEMBL19717426 | 0.86 | MAPT (0.36) | MAPTGAAKDM4EALDH1A1HPGD | |
| SCHEMBL7238065 | 0.77 | ALDH1A1 (0.36) | MAPTGAAKDM4EALDH1A1HPGD | |
| SCHEMBL19734735 | 0.77 | ALDH1A1 (0.43) | MAPTGAAKDM4EALDH1A1HPGD | |
| SCHEMBL4650747 | 0.72 | KDM4E (0.36) | MAPTGAAKDM4EALDH1A1HPGD | |
| SCHEMBL19734743 | 0.70 | ALDH1A1 (0.33) | MAPTGAAKDM4EALDH1A1HPGD | |
| SCHEMBL29658711 | 0.69 | ALDH1A1 (0.47) | MAPTGAAKDM4EALDH1A1HPGD | |
| SCHEMBL19716920 | 0.69 | ALDH1A1 (0.47) | MAPTGAAKDM4EALDH1A1HPGD | |
| SCHEMBL11826533 | 0.69 | ALDH1A1 (0.37) | GAAKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563043-B | Substituted pyridines as inhibitors of DNMT1 | 葛兰素史密斯克莱知识产权发展有限公司 | 2022-05-31 | — | — | CN | disclosed |