SCHEMBL29660673

SCHEMBL29660673

CCOC(=O)C(F)(F)c1ccc(Br)cn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
NPSR1 Q6W5P4 3/20 0.40
MAPT P10636 3/20 0.40
LMNA P02545 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MAPK1 P28482 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
MEN1 O00255 1/20 0.40
S1PR4 O95977 1/20 0.40
S1PR1 P21453 1/20 0.40
KMT2A Q03164 1/20 0.40
RAB9A P51151 2/20 0.39
CES2 O00748 1/20 0.38
ACHE P22303 1/20 0.38
CES1 P23141 1/20 0.38
DGAT2 Q96PD7 1/20 0.38
HTT P42858 2/20 0.37
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11913028 1.00 ALDH1A1 (0.40) ALDH1A1NPSR1MAPTLMNASMN1; SMN2
SCHEMBL25160774 0.89 ALDH1A1 (0.38) ALDH1A1MAPTLMNASMN1; SMN2MEN1
SCHEMBL14466869 0.87 ALDH1A1 (0.39) ALDH1A1NPSR1MAPTLMNASMN1; SMN2
SCHEMBL3891001 0.85 KDM4E (0.48) ALDH1A1NPSR1MAPTSMN1; SMN2MAPK1
SCHEMBL15118626 0.84 LMNA (0.41) ALDH1A1NPSR1MAPTLMNASMN1; SMN2
SCHEMBL17113764 0.84 POLB (0.49) ALDH1A1NPSR1MAPTLMNASMN1; SMN2
SCHEMBL20406093 0.84 KMT2A (0.41) ALDH1A1NPSR1MAPTLMNASMN1; SMN2
SCHEMBL161047 0.84 MAPT (0.42) ALDH1A1NPSR1MAPTLMNASMN1; SMN2
SCHEMBL14332032 0.82 HTT (0.46) ALDH1A1NPSR1MAPTLMNASMN1; SMN2
SCHEMBL17118220 0.82 GABRA1 (0.37) NPSR1MAPTLMNASMN1; SMN2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116675672-B Preparation method of antifungal medicine 北京康立生医药技术开发有限公司 2025-04-25 CN disclosed
CN-119798219-A Preparation method of octreonazole 长治医学院 2025-04-11 CN disclosed
CN-111170991-B Antiproliferative compounds and methods of synthesis thereof 细胞基因公司 2023-10-31 CN disclosed
CN-116675672-A New preparation method of antifungal medicine 北京康立生医药技术开发有限公司 2023-09-01 CN disclosed
EP-3397629-B1 METALLOENZYME INHIBITOR COMPOUNDS NQP 1598 LTD (KY) 2023-04-19 EP disclosed
CN-109970629-B Process for preparing antifungal compounds 迈科维亚医药公司 2023-04-11 CN disclosed
EP-4005638-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2022-06-01 EP disclosed