Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | AGER | Q15109 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28911965 | 0.76 | PARP1 (0.40) | SPRKDM4EALDH1A1MAPTCYP3A4 | |
| SCHEMBL30066845 | 0.75 | KDM4E (0.41) | SPRKDM4EALDH1A1MAPTCYP3A4 | |
| SCHEMBL29661036 | 0.73 | KDM4E (0.39) | SPRKDM4EALDH1A1MAPTCYP3A4 | |
| SCHEMBL29660938 | 0.72 | PDK2 (0.41) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL27755306 | 0.71 | NOS3 (0.38) | ALDH1A1L3MBTL1MKNK1MKNK2CYP1A2 | |
| SCHEMBL22031860 | 0.70 | PARP1 (0.44) | KDM4EALDH1A1MAPTCYP3A4ALOX15 | |
| SCHEMBL29818101 | 0.68 | KDM4E (0.47) | KDM4EALDH1A1MAPTTSHRPARP1 | |
| SCHEMBL27775621 | 0.68 | SMN1; SMN2 (0.38) | ALDH1A1L3MBTL1CYP1A2P2RX7 | |
| SCHEMBL31292327 | 0.68 | KDM4E (0.34) | KDM4EALOX15 | |
| SCHEMBL29660939 | 0.68 | KDM4E (0.37) | KDM4EALDH1A1MAPTCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003516-A1 | PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS | TMEM16A LIMITED (GB) | 2022-06-01 | — | — | EP | disclosed |