Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29660959 | 0.87 | PDK2 (0.38) | PDK2KDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL30829295 | 0.81 | L3MBTL1 (0.48) | PDK2KDM4EALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL29661036 | 0.77 | KDM4E (0.39) | PDK2KDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL30066845 | 0.76 | KDM4E (0.41) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL31026277 | 0.76 | PDK2 (0.42) | PDK2KDM4EMAPTALDH1A1BLM | |
| SCHEMBL22443382 | 0.74 | PDK2 (0.51) | PDK2KDM4EMAPTALDH1A1TSHR | |
| SCHEMBL28911965 | 0.74 | PARP1 (0.40) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL29660939 | 0.72 | KDM4E (0.37) | PDK2KDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL29660941 | 0.72 | SPR (0.37) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL18726259 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777126-A | Imidazopyridines as IRAK4 degradants and uses thereof | 武汉人福创新药物研发中心有限公司 | 2024-03-29 | — | — | CN | disclosed |
| EP-4003516-A1 | PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS | TMEM16A LIMITED (GB) | 2022-06-01 | — | — | EP | disclosed |