Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.40 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22918393 | 1.00 | RAB9A (0.45) | RAB9ASMN1; SMN2KDM1AGAAMAPT | |
| SCHEMBL22918166 | 0.83 | ERN1 (0.48) | RAB9ASMN1; SMN2KDM1AGAAMAPT | |
| SCHEMBL23599560 | 0.82 | CCR5 (0.60) | RAB9ASMN1; SMN2MAPTCCR5NPC1 | |
| SCHEMBL20521874 | 0.81 | KDM1A (0.48) | RAB9ASMN1; SMN2KDM1AMAPTNPC1 | |
| SCHEMBL30221893 | 0.81 | KDM1A (0.48) | RAB9ASMN1; SMN2KDM1AMAPTNPC1 | |
| SCHEMBL26087192 | 0.79 | ERN1 (0.47) | RAB9ASMN1; SMN2KDM1AGAAMAPT | |
| SCHEMBL24631045 | 0.78 | NPC1 (0.43) | RAB9ASMN1; SMN2KDM1ANPC1MRGPRX4 | |
| SCHEMBL416139 | 0.77 | KDM1A (0.48) | RAB9ASMN1; SMN2KDM1AMAPTNPC1 | |
| SCHEMBL22918092 | 0.77 | ELANE (0.47) | RAB9ASMN1; SMN2KDM1ACCR5NPC1 | |
| SCHEMBL19667234 | 0.77 | FOLH1 (0.56) | NPC1MRGPRX4PTGER1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114616226-B | Pyridine derivatives as TMEM16A modulators for the treatment of respiratory disorders | TMEM16A有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-114616226-A | Pyridine derivatives as TMEM16A modulators for the treatment of respiratory disorders | TMEM16A有限公司 | 2022-06-10 | — | — | CN | disclosed |
| EP-4003516-A1 | PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS | TMEM16A LIMITED (GB) | 2022-06-01 | — | — | EP | disclosed |