Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26087192 | 0.96 | ERN1 (0.47) | ERN1SMN1; SMN2MAPTL3MBTL1HPGD | |
| SCHEMBL18893873 | 0.88 | ERN1 (0.52) | ERN1SMN1; SMN2MAPTL3MBTL1CCNB2 | |
| SCHEMBL31113771 | 0.86 | ERN1 (0.54) | ERN1SMN1; SMN2MAPTL3MBTL1CCNB2 | |
| SCHEMBL1539204 | 0.85 | SMN1; SMN2 (0.52) | ERN1SMN1; SMN2MAPTL3MBTL1HPGD | |
| SCHEMBL24252546 | 0.84 | MAPT (0.53) | ERN1SMN1; SMN2MAPTL3MBTL1HPGD | |
| SCHEMBL207723 | 0.84 | SMN1; SMN2 (0.49) | ERN1SMN1; SMN2MAPTL3MBTL1HPGD | |
| SCHEMBL31588911 | 0.83 | MAPT (0.66) | ERN1SMN1; SMN2MAPTL3MBTL1HPGD | |
| SCHEMBL22918393 | 0.83 | RAB9A (0.45) | ERN1SMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL29660969 | 0.83 | RAB9A (0.45) | ERN1SMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL20521874 | 0.83 | KDM1A (0.48) | SMN1; SMN2MAPTL3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220235006-A1 | PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS | Enterprise Therapeutics Limited (GB) | 2022-07-28 | — | — | US | disclosed |
| WO-2021014166-A1 | PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS | Enterprise Therapeutics Limited (GB) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220235006-A1 | PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS | TMEM109, TMEM70, TMEM120A | ERN1 2810/4885SMN1; SMN2 1492/4885MAPT 4043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.