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SCHEMBL29663842

SCHEMBL29663842

C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ TFPI P10646 1/20 0.57
▸ NPY4R P50391 13/20 0.54
▸ NPY1R P25929 8/20 0.54
▸ NPY5R Q15761 7/20 0.54
▸ NPY2R P49146 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29663833 0.94 OPRD1 (0.53) TFPI
SCHEMBL29635274 0.89 TFPI (0.55) TFPINPY4RNPY1RNPY5RNPY2R
SCHEMBL31571458 0.88 NPY4R (0.60) NPY4RNPY1RNPY5RNPY2R
SCHEMBL31370896 0.88 TFPI (0.57) TFPINPY4RNPY1RNPY5R
SCHEMBL31411175 0.88 TFPI (0.57) TFPINPY4RNPY1RNPY5R
SCHEMBL30773467 0.88 NPY4R (0.55) TFPINPY4RNPY1RNPY5RNPY2R
SCHEMBL29591917 0.87 NPY4R (0.54) TFPINPY4RNPY1RNPY5RNPY2R
SCHEMBL10680110 0.87 NPY4R (0.54) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30274541 0.87 NPY4R (0.63) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30900790 0.86 TFPI (0.65) TFPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12214015-B2 Use of c-type natriuretic peptide variants to treat osteoarthritis BIOMARIN PHARMACEUTICAL INC. (US) 2025-02-04 — — US disclosed
US-20220160836-A1 USE OF C-TYPE NATRIURETIC PEPTIDE VARIANTS TO TREAT OSTEOARTHRITIS BIOMARIN PHARMACEUTICAL INC. 2022-05-26 — — US disclosed
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