Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.45 |
| ▸ | F9 | P00740 | 1/20 | 0.45 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21763 | 1.00 | NR4A2 (0.59) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL9946041 | 0.88 | NR4A2 (0.57) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL2562469 | 0.85 | NR4A2 (0.61) | NR4A2NPC1RAB9AENPP2NR4A1 | |
| SCHEMBL2562164 | 0.84 | ENPP2 (0.50) | NR4A2NPC1RAB9AENPP2MEN1 | |
| SCHEMBL2558815 | 0.83 | NR4A2 (0.46) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL2556153 | 0.83 | NR4A2 (0.60) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL29954245 | 0.83 | NR4A2 (0.60) | NR4A2NPC1RAB9AMAOBMAOA | |
| SCHEMBL15332443 | 0.82 | CCNB2 (0.52) | NR4A2NPC1RAB9AMAOBENPP2 | |
| SCHEMBL4317982 | 0.82 | MAOB (0.51) | MAOBENPP2SPHK2SPHK1F9 | |
| SCHEMBL31240558 | 0.82 | MAOB (0.51) | MAOBENPP2SPHK2SPHK1F9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4067355-A1 | SPIRO-CONDENSED PYRROLIDINE DERIVATIVES AS DEUBIQUITYLATING ENZYME (DUB) INHIBITORS | Mission Therapeutics Limited (GB) | 2022-10-05 | — | — | EP | disclosed |
| EP-3423454-B1 | SPIRO-CONDENSED PYRROLIDINE DERIVATIVES AS DEUBIQUITYLATING ENZYMES (DUB) INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2022-05-25 | — | — | EP | disclosed |