Bupleurotoxin

Bupleurotoxin

SCHEMBL29664260

CCC[C@H](O)CC/C=C/C=C/C#CC#C/C=C\CO

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SOAT2 O75908 1/20 0.38
SOAT1 P35610 1/20 0.38
FAAH O00519 1/20 0.34
CNR1 P21554 1/20 0.34
CNR2 P34972 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oenanthotoxin SCHEMBL1170273 1.00 SOAT2 (0.38) SOAT2SOAT1FAAHCNR1CNR2
Oenanthotoxin SCHEMBL1170270 1.00 SOAT2 (0.38) SOAT2SOAT1FAAHCNR1CNR2
SCHEMBL30766358 0.82 FAAH (0.42) SOAT2SOAT1FAAHCNR1CNR2
SCHEMBL28071097 0.79 HMGCR (0.40) SOAT2SOAT1FAAHCNR1CNR2
SCHEMBL28102522 0.79 HMGCR (0.40) SOAT2SOAT1FAAHCNR1CNR2
Acetylbupleurotoxin SCHEMBL30308945 0.77 SOAT2 (0.47) SOAT2SOAT1FAAHCNR1CNR2
SCHEMBL27697824 0.76 FASN (0.45) FAAHCNR1CNR2
SCHEMBL28070993 0.76 FASN (0.45) FAAHCNR1CNR2
SCHEMBL29627131 0.76 FASN (0.45) FAAHCNR1CNR2
SCHEMBL15827692 0.68 ALDH1A1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210933-A1 COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASE COMPRISING HYDROLYSIS EXTRACT OF PULSATILLA KOREANA AND ANEMONE RADDEANA AS ACTIVE INGREDIENT BACK, Ju Youn (KR) 2023-07-06 US claimed
EP-4162942-A1 COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASE, COMPRISING HYDROLYSIS EXTRACT OF PULSATILLA KOREANA AND ANEMONE RADDEANA AS ACTIVE INGREDIENT Back, Ju Youn (KR) 2023-04-12 EP claimed
CN-115916232-B Composition for preventing or treating inflammatory diseases comprising hydrolyzed extracts of pulsatilla chinensis and anemone polycephalum as active ingredients 白周娟 2024-10-01 CN disclosed
US-11951145-B2 Composition for preventing or treating cancer comprising extracts of anemone raddeana, Lonicera species, and aralia elata containing high concentration of antitumor saponins, and method for preparing same BACK, Ju Youn (KR) 2024-04-09 US disclosed
US-20230210933-A1 COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASE COMPRISING HYDROLYSIS EXTRACT OF PULSATILLA KOREANA AND ANEMONE RADDEANA AS ACTIVE INGREDIENT BACK, Ju Youn (KR) 2023-07-06 US disclosed
EP-4162942-A1 COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASE, COMPRISING HYDROLYSIS EXTRACT OF PULSATILLA KOREANA AND ANEMONE RADDEANA AS ACTIVE INGREDIENT Back, Ju Youn (KR) 2023-04-12 EP disclosed
CN-112074285-B Pharmaceutical composition comprising extracts of anemone multocida and Lonicera for preventing or treating solid tumor, and its preparation method 白周娟 2022-05-17 CN disclosed