Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29664350 | 0.81 | ALDH1A1 (0.57) | L3MBTL1 | |
| SCHEMBL29664632 | 0.79 | RAB9A (0.71) | NPC1POLBRAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL29664336 | 0.76 | RAB9A (0.45) | NPC1POLBRAB9AEPHX2SMN1; SMN2 | |
| SCHEMBL23412427 | 0.73 | KDM4E (0.50) | POLBRAB9AL3MBTL1HDAC1 | |
| SCHEMBL4418032 | 0.72 | NTRK1 (0.48) | POLBRAB9AEPHX2NTRK1SMN1; SMN2 | |
| SCHEMBL3992133 | 0.71 | MAPT (0.60) | NPC1POLBRAB9ANTRK1SMN1; SMN2 | |
| SCHEMBL24404235 | 0.71 | RAB9A (0.38) | RAB9AEPHX2 | |
| SCHEMBL6788678 | 0.69 | ALDH1A1 (0.51) | SMN1; SMN2GFER | |
| SCHEMBL9293207 | 0.69 | ALDH1A1 (0.49) | NPC1POLBRAB9ANTRK1SMN1; SMN2 | |
| SCHEMBL2860521 | 0.68 | MAPT (0.42) | NPC1POLBRAB9ASMN1; SMN2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022096679-A1 | PROTEIN-PROTEIN INTERACTION MODULATORS OF AURORA KINASE A AND THEIR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER | EBERHARD KARLS UNIVERSITÄT TÜBINGEN (DE) | 2022-05-12 | — | — | WO | disclosed |