Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL796509 | 1.00 | ALOX15 (0.39) | ALOX15CASP1GAACASP7ALK | |
| SCHEMBL16294313 | 0.85 | ALOX15 (0.39) | ALOX15CASP1ERN1BCL2MCL1 | |
| Hydrochloric Acid SCHEMBL29015486 | 0.83 | ALOX15 (0.38) | ALOX15CASP1ERN1BCL2MCL1 | |
| SCHEMBL12861090 | 0.77 | SRC (0.32) | — | |
| SCHEMBL4297621 | 0.77 | NT5E (0.49) | GAAALKPIM1CHEK1AKT1 | |
| SCHEMBL30950664 | 0.77 | NT5E (0.49) | GAAALKPIM1CHEK1AKT1 | |
| SCHEMBL29665280 | 0.77 | NT5E (0.49) | GAAALKPIM1CHEK1AKT1 | |
| SCHEMBL12034330 | 0.77 | TRPA1 (0.45) | ALOX15GAAIDO1LMNAMAPT | |
| SCHEMBL9998167 | 0.77 | ERN1 (0.37) | ERN1 | |
| SCHEMBL2719952 | 0.77 | KDM4E (0.44) | HTTIDO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118388416-A | Synthesis method of 4-chloro-6-bromocinnoline | 凯美克(上海)医药科技有限公司 | 2024-07-26 | — | — | CN | claimed |
| CN-118388416-A | Synthesis method of 4-chloro-6-bromocinnoline | 凯美克(上海)医药科技有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118388416-A | Synthesis method of 4-chloro-6-bromocinnoline | 凯美克(上海)医药科技有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-4251617-A1 | (AZA)QUINOLINE 4-AMINES DERIVATIVES AS P2X3 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022112491-A1 | (AZA)QUINOLINE 4-AMINES DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-02 | — | — | WO | disclosed |