Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | DHPS | P49366 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 3/20 | 0.38 |
| ▸ | GOT1 | P17174 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24513509 | 1.00 | TAS2R14 (0.43) | TAS2R14TRPA1DHPSTRPV1L3MBTL1 | |
| SCHEMBL29665915 | 0.88 | JAK3 (0.44) | TAS2R14TRPA1L3MBTL1KMT2AMEN1 | |
| SCHEMBL24512903 | 0.88 | JAK3 (0.44) | TAS2R14TRPA1L3MBTL1KMT2AMEN1 | |
| SCHEMBL29665802 | 0.86 | TNKS (0.43) | TAS2R14TRPA1TRPV1PTGESBRD4 | |
| SCHEMBL29665826 | 0.85 | JAK2 (0.43) | TAS2R14TRPA1JAK2JAK1TYK2 | |
| SCHEMBL24513513 | 0.85 | JAK2 (0.43) | TAS2R14TRPA1JAK2JAK1TYK2 | |
| SCHEMBL29316483 | 0.84 | AR (0.43) | TAS2R14DHPSL3MBTL1KMT2AATM | |
| SCHEMBL24512973 | 0.82 | TRPA1 (0.41) | TAS2R14TRPA1KMT2AMEN1POLB | |
| SCHEMBL29665854 | 0.82 | TRPA1 (0.41) | TAS2R14TRPA1KMT2AMEN1POLB | |
| SCHEMBL24512972 | 0.80 | TRPA1 (0.43) | TAS2R14TRPA1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259604-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022125636-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |