Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24512937 | 0.87 | TRPA1 (0.42) | TAS2R14PTGESTRPA1AURKACDK1 | |
| SCHEMBL29665833 | 0.87 | TRPA1 (0.42) | TAS2R14PTGESTRPA1AURKACDK1 | |
| SCHEMBL29665983 | 0.86 | PTGES (0.51) | TAS2R14PTGESTRPA1AURKACDK1 | |
| SCHEMBL29665884 | 0.86 | TAS2R14 (0.43) | TAS2R14PTGESTRPA1TRPV1BRD4 | |
| SCHEMBL24513509 | 0.86 | TAS2R14 (0.43) | TAS2R14PTGESTRPA1TRPV1BRD4 | |
| SCHEMBL24512986 | 0.85 | TRPA1 (0.45) | TAS2R14PTGESTRPA1AURKACDK1 | |
| SCHEMBL24512927 | 0.85 | TRPA1 (0.45) | TAS2R14PTGESTRPA1AR | |
| SCHEMBL29665834 | 0.85 | TRPA1 (0.45) | TAS2R14PTGESTRPA1AR | |
| SCHEMBL29665808 | 0.85 | TRPA1 (0.45) | TAS2R14PTGESTRPA1AURKACDK1 | |
| SCHEMBL24512991 | 0.84 | TRPA1 (0.44) | TAS2R14PTGESTRPA1AURKACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259604-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022125636-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |