Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.51 |
| ▸ | MMP9 | P14780 | 2/20 | 0.51 |
| ▸ | MMP8 | P22894 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13221018 | 0.92 | NPBWR1 (0.68) | NPBWR1RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL4497810 | 0.89 | NPBWR1 (0.65) | NPBWR1RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL4487881 | 0.87 | MMP2 (0.66) | NPBWR1RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL4497816 | 0.86 | NPBWR1 (0.74) | NPBWR1RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL2250346 | 0.81 | NPBWR1 (0.60) | NPBWR1RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL3190704 | 0.80 | AMY1A (0.59) | NPBWR1RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL3202735 | 0.80 | NPBWR1 (0.81) | NPBWR1RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL10579818 | 0.80 | NPBWR1 (0.55) | NPBWR1RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL3337243 | 0.80 | NPBWR1 (0.81) | NPBWR1RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL4487886 | 0.80 | NPBWR1 (0.76) | NPBWR1RAB9ANPC1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777051-B2 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20050038067-A1 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2005-02-17 | — | — | US | disclosed |
| WO-2005002503-A2 | ASYMMETRIC BENZIMIDAZOLES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038067-A1 | Asymmetric benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNJ1, KCNJ11 | NPBWR1 4235/4885RAB9A 3606/4885NPC1 709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.