Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30071654 | 0.83 | GAA (0.60) | GAAGLAGFERALDH1A1KDM4E | |
| SCHEMBL24484076 | 0.83 | GAA (0.54) | GAAGLAGFERALDH1A1KDM4E | |
| SCHEMBL1628544 | 0.79 | GAA (0.50) | GAAGLAGFERALDH1A1KDM4E | |
| SCHEMBL29670186 | 0.75 | CA1 (0.46) | GAAGFERCA1CA2ENPP2 | |
| SCHEMBL31510674 | 0.74 | MEN1 (0.72) | L3MBTL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL31510780 | 0.73 | CYP19A1 (0.55) | CA1CA2ENPP2ALDH1A1MEN1 | |
| SCHEMBL24470004 | 0.73 | CA1 (0.44) | GAAGFERCA1CA2ENPP2 | |
| SCHEMBL17982136 | 0.72 | ALDH1A1 (0.54) | GAAGLAGFERALDH1A1KDM4E | |
| SCHEMBL24484080 | 0.72 | SNCA (0.48) | GAAGLAGFERALDH1A1KDM4E | |
| SCHEMBL257917 | 0.72 | CA2 (0.86) | CA1CA2ENPP2SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115384-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-02 | — | — | WO | disclosed |