Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 10/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419935 | 1.00 | PRSS1 (0.46) | PRSS1LMNAMAPTAAK1APEX1 | |
| SCHEMBL1464213 | 0.89 | PRSS1 (0.49) | PRSS1MAPTAAK1APEX1ALDH1A1 | |
| SCHEMBL30461744 | 0.85 | MAPT (0.44) | PRSS1LMNAMAPTAAK1APEX1 | |
| SCHEMBL418892 | 0.85 | MAPT (0.44) | PRSS1LMNAMAPTAAK1APEX1 | |
| SCHEMBL26324516 | 0.81 | HTT (0.44) | PRSS1MAPTAAK1APEX1PTGER4 | |
| SCHEMBL2927441 | 0.81 | PRSS1 (0.49) | PRSS1MAPTPTGER4ALDH1A1 | |
| SCHEMBL11786540 | 0.81 | LMNA (0.46) | LMNAMAPTAPEX1L3MBTL1CYP1A2 | |
| SCHEMBL2949748 | 0.79 | TLR8 (0.45) | PRSS1MAPTPTGER4ALDH1A1HDAC3 | |
| SCHEMBL17678064 | 0.78 | KDM4E (0.45) | PRSS1ALDH1A1EGFR | |
| SCHEMBL6570671 | 0.78 | CYP1A2 (0.43) | PRSS1LMNAMAPTAPEX1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022115384-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-02 | — | — | WO | disclosed |