Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PLEC | Q15149 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949748 | 0.89 | TLR8 (0.45) | PRSS1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL21590211 | 0.85 | CCNC (0.44) | HTTCCNCCDK8KDM4EMAPT | |
| SCHEMBL29502113 | 0.85 | ALDH1A1 (0.54) | HTTPRSS1KDM4EALDH1A1GAA | |
| SCHEMBL2018111 | 0.85 | ALDH1A1 (0.54) | HTTPRSS1KDM4EALDH1A1GAA | |
| SCHEMBL18731527 | 0.84 | PRSS1 (0.36) | HTTPRSS1KDM4EALDH1A1GAA | |
| SCHEMBL419935 | 0.81 | PRSS1 (0.46) | PRSS1ALDH1A1MAPTAAK1HDAC3 | |
| SCHEMBL29670372 | 0.81 | PRSS1 (0.46) | PRSS1ALDH1A1MAPTAAK1HDAC3 | |
| SCHEMBL15774438 | 0.81 | PTGER4 (0.60) | PRSS1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL17678059 | 0.81 | NCF1 (0.44) | PRSS1KDM4EALDH1A1GAAAAK1 | |
| SCHEMBL3637289 | 0.79 | HDAC6 (0.59) | HTTPRSS1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | DUKE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | DUKE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767298-B2 | Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase | TAB1, CHUK, TGFBR1 | HTT 4589/4885CCNC 1252/4885CDK8 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.