Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13457191 | 0.83 | CYP1A2 (0.45) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL29070081 | 0.77 | MAOB (0.63) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL10687383 | 0.75 | APP (0.58) | CYP3A4TSHRAPPIDO1MAOB | |
| SCHEMBL13457196 | 0.75 | ALDH1A1 (0.43) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL9507201 | 0.74 | APP (0.46) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL19297784 | 0.73 | APP (0.49) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL9508531 | 0.71 | SLC6A4 (0.51) | CYP2D6TSHRAPPIDO1MAOB | |
| SCHEMBL17926791 | 0.71 | CYP1A2 (0.46) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL9507453 | 0.70 | IDO1 (0.45) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL31011604 | 0.70 | APP (0.49) | TSHRAPPIDO1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244213-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022103899-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-19 | — | — | WO | disclosed |