Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507453 | 0.90 | IDO1 (0.45) | APPMAOBTSHRMAOAALDH1A1 | |
| SCHEMBL9508531 | 0.82 | SLC6A4 (0.51) | APPMAOBTSHRMAOAALDH1A1 | |
| SCHEMBL10687383 | 0.79 | APP (0.58) | APPMAOBTSHRMAOAALDH1A1 | |
| SCHEMBL19297784 | 0.78 | APP (0.49) | APPMAOBTSHRMAOAALDH1A1 | |
| SCHEMBL15211340 | 0.75 | MAOB (0.45) | APPMAOBTSHRMAOAALDH1A1 | |
| SCHEMBL9509583 | 0.75 | SLC6A4 (0.44) | IDO1CYP1A2CYP2E1CYP3A4CYP2C8 | |
| SCHEMBL29673296 | 0.74 | CYP1A2 (0.43) | APPMAOBTSHRMAOADAO | |
| SCHEMBL5970893 | 0.73 | APP (0.47) | APPMAOBTSHRMAOAALDH1A1 | |
| SCHEMBL11837887 | 0.72 | ALDH1A1 (0.40) | ALDH1A1GFERCYP1A2CYP2E1CYP3A4 | |
| SCHEMBL9507588 | 0.72 | MAOB (0.45) | APPMAOBTSHRMAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358305-B1 | MERCAPTO-PHENYLALCANOYLAMINO ACID AMIDES, THEIR PREPARATION AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1993-08-25 | — | — | EP | disclosed |
| US-5124322-A | Antiarthritic agents | BEECHAM GROUP P.L.C. (GB) | 1992-06-23 | — | — | US | disclosed |
| EP-0358305-A1 | Mercapto-phenylalcanoylamino acid amides, their preparation and their use as collagenase inhibitors | BEECHAM GROUP PLC (GB) | 1990-03-14 | — | — | EP | disclosed |