Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA6 | P23280 | 2/20 | 0.55 |
| ▸ | CA7 | P43166 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424320 | 1.00 | POLB (0.55) | POLBL3MBTL1CA12CA1CA2 | |
| SCHEMBL10816991 | 0.86 | SIRT1 (0.44) | POLBL3MBTL1CA12CA1CA2 | |
| SCHEMBL31248332 | 0.85 | CA12 (0.55) | POLBL3MBTL1CA12CA1CA2 | |
| SCHEMBL10652398 | 0.83 | PKM (0.49) | POLBCA12CA1CA2CA9 | |
| SCHEMBL9350997 | 0.82 | KDM4E (0.57) | POLBL3MBTL1CA12CA1CA2 | |
| SCHEMBL27567123 | 0.81 | KDM4E (0.55) | POLBL3MBTL1CA12CA1CA2 | |
| SCHEMBL27567125 | 0.81 | KDM4E (0.55) | POLBL3MBTL1CA12CA1CA2 | |
| SCHEMBL7922220 | 0.81 | CDC25B (0.50) | POLBL3MBTL1CA12CA1CA2 | |
| SCHEMBL396004 | 0.81 | TDP1 (0.61) | POLBL3MBTL1KDM4EMAPTCDC25B | |
| SCHEMBL3779029 | 0.79 | CDC25B (0.49) | POLBL3MBTL1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244213-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022103899-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-19 | — | — | WO | disclosed |