Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.42 |
| ▸ | BMP1 | P13497 | 2/20 | 0.41 |
| ▸ | APC | P25054 | 3/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | GNPAT | O15228 | 1/20 | 0.39 |
| ▸ | TFPI | P10646 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22648206 | 0.96 | KEAP1 (0.47) | KEAP1SIRT5BMP1APCECE1 | |
| SCHEMBL29673327 | 0.93 | GNPAT (0.46) | KEAP1SIRT5BMP1APCECE1 | |
| SCHEMBL29517692 | 0.93 | KEAP1 (0.44) | KEAP1SIRT5BMP1ECE1GNPAT | |
| SCHEMBL22640903 | 0.89 | TLR2 (0.46) | KEAP1SIRT5GRIN2DGRIN3BGRIN1 | |
| SCHEMBL22648217 | 0.89 | TLR2 (0.46) | KEAP1SIRT5GRIN2DGRIN3BGRIN1 | |
| SCHEMBL24616816 | 0.88 | GNPAT (0.49) | KEAP1SIRT5BMP1ECE1GRIN2D | |
| SCHEMBL22648312 | 0.88 | GNPAT (0.49) | KEAP1SIRT5BMP1ECE1GRIN2D | |
| SCHEMBL22640897 | 0.88 | GNPAT (0.49) | KEAP1SIRT5BMP1ECE1GRIN2D | |
| SCHEMBL24616715 | 0.88 | GNPAT (0.49) | KEAP1SIRT5BMP1ECE1GRIN2D | |
| SCHEMBL22640926 | 0.88 | GNPAT (0.49) | KEAP1SIRT5BMP1ECE1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220220155-A1 | VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (ES) | 2022-07-14 | — | — | US | claimed |
| US-20220220155-A1 | VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (ES) | 2022-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220220155-A1 | VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF | LDLR, APOB, HDLBP | KEAP1 730/4885SIRT5 2090/4885BMP1 4588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.