Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Squalamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.90 |
| ▸ | SLC10A1 | Q14973 | 4/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.48 |
| ▸ | SLC10A2 | Q12908 | 4/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Squalamine SCHEMBL313361 | 1.00 | PTPN1 (0.90) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 | |
| Squalamine SCHEMBL29673380 | 0.99 | PTPN1 (0.89) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 | |
| Squalamine SCHEMBL22397773 | 0.97 | PTPN1 (0.86) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 | |
| Squalamine SCHEMBL14430016 | 0.96 | PTPN1 (0.97) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 | |
| Squalamine SCHEMBL22356672 | 0.96 | PTPN1 (0.97) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 | |
| Squalamine SCHEMBL21248627 | 0.96 | PTPN1 (0.97) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 | |
| Squalamine SCHEMBL20850040 | 0.96 | PTPN1 (0.97) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 | |
| Squalamine SCHEMBL12836 | 0.96 | PTPN1 (0.97) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 | |
| Squalamine SCHEMBL17359656 | 0.96 | PTPN1 (0.97) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 | |
| Squalamine SCHEMBL18838926 | 0.96 | PTPN1 (0.97) | PTPN1SLC10A1NR1H4GPBAR1SLC10A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11440936-B2 | Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same | ENTERIN, INC. (US) | 2022-09-13 | — | — | US | disclosed |
| US-11419879-B2 | Methods for treating and preventing viral infections | ENTERIN, INC. (US) | 2022-08-23 | — | — | US | disclosed |
| US-20220220148-A1 | METHODS AND COMPOSITIONS FOR STIMULATION OF THE INTESTINAL ENTEROENDOCRINE SYSTEM FOR TREATING DISEASES OR CONDITIONS RELATED TO THE SAME | ENTERIN INC. (US) | 2022-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220220148-A1 | METHODS AND COMPOSITIONS FOR STIMULATION OF THE INTESTINAL ENTEROENDOCRINE SYSTEM FOR TREATING DISEASES OR CONDITIONS RELATED TO THE SAME | SI, VIP, ASNS | PTPN1 4093/4885SLC10A1 577/4885NR1H4 296/4885 |
| US-11440936-B2 | Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same | SI, VIP, ASNS | PTPN1 4093/4885SLC10A1 577/4885NR1H4 296/4885 |
| US-11419879-B2 | Methods for treating and preventing viral infections | STING1, TSLP, MAVS | PTPN1 2620/4885SLC10A1 114/4885NR1H4 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.