Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22795445 | 1.00 | ALDH1A1 (0.46) | ALDH1A1MAPK1SLC6A7L3MBTL1GBA1 | |
| SCHEMBL22795084 | 1.00 | ALDH1A1 (0.46) | ALDH1A1MAPK1SLC6A7L3MBTL1GBA1 | |
| SCHEMBL22795449 | 1.00 | ALDH1A1 (0.46) | ALDH1A1MAPK1SLC6A7L3MBTL1GBA1 | |
| SCHEMBL21341955 | 0.83 | AVPR1A (0.54) | ALDH1A1MAPK1L3MBTL1AVPR1APROKR1 | |
| SCHEMBL22795079 | 0.78 | SLC6A7 (0.49) | ALDH1A1SLC6A7L3MBTL1GBA1GSK3B | |
| SCHEMBL22795435 | 0.78 | SLC6A7 (0.49) | ALDH1A1SLC6A7L3MBTL1GBA1GSK3B | |
| SCHEMBL22795442 | 0.78 | SLC6A7 (0.49) | ALDH1A1SLC6A7L3MBTL1GBA1GSK3B | |
| SCHEMBL31368522 | 0.78 | KAT2B (0.46) | ALDH1A1L3MBTL1AVPR1APROKR1GSK3B | |
| SCHEMBL22795549 | 0.75 | GBA1 (0.43) | GBA1PROKR1GSK3BROCK2ROCK1 | |
| SCHEMBL22795028 | 0.75 | GBA1 (0.43) | GBA1PROKR1GSK3BROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12115154-B2 | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) | SRX CARDIO, LLC (US) | 2024-10-15 | — | — | US | disclosed |
| US-20220267269-A1 | COMPOUNDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | SRX CARDIO LLC (US) | 2022-08-25 | — | — | US | disclosed |
| US-20220193058-A1 | COMPOUNDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | SRX CARDIO, LLC | 2022-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220193058-A1 | COMPOUNDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | PCSK9, PCSK6, PCSK7 | ALDH1A1 4740/4885MAPK1 2562/4885SLC6A7 4716/4885 |
| US-12115154-B2 | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) | PCSK9, PCSK6, PCSK7 | ALDH1A1 4740/4885MAPK1 2562/4885SLC6A7 4716/4885 |
| US-20220267269-A1 | COMPOUNDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | PCSK9, PCSK6, PCSK7 | ALDH1A1 4740/4885MAPK1 2562/4885SLC6A7 4716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.