Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29391341 | 0.84 | IKBKB (0.36) | ALDH1A1ATMMETAP2NNMT | |
| SCHEMBL18989231 | 0.82 | CDC7 (0.36) | CDC7ALDH1A1NNMT | |
| SCHEMBL18286040 | 0.82 | ALDH1A1 (0.31) | ALDH1A1ATMMETAP2 | |
| Hydrochloric Acid SCHEMBL28435492 | 0.78 | HCAR2 (0.37) | ALDH1A1NNMT | |
| SCHEMBL15559344 | 0.78 | KDM4E (0.36) | — | |
| SCHEMBL23012168 | 0.77 | PARP10 (0.35) | — | |
| SCHEMBL27815355 | 0.77 | GABRP (0.42) | CDC7 | |
| SCHEMBL27866307 | 0.75 | PLA2G2A (0.46) | CDC7ALDH1A1 | |
| Sulfuric Acid SCHEMBL28426836 | 0.74 | HCAR2 (0.34) | NNMT | |
| SCHEMBL918559 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262807-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |