Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | LTK | P29376 | 1/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | MST1R | Q04912 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2376041 | 0.85 | MAPK8 (0.56) | MAOAPLK4DAPK3PIM1PDGFRA | |
| SCHEMBL11697643 | 0.77 | PKM (0.53) | ALDH1A1MIFMAOBKMT2AMEN1 | |
| Anthrone SCHEMBL29357010 | 0.74 | MAOA (1.00) | MAOACES1BCHEALDH1A1CYP1A2 | |
| Anthrone SCHEMBL1527782 | 0.74 | MAOA (1.00) | MAOACES1BCHEALDH1A1CYP1A2 | |
| Anthrone SCHEMBL29448801 | 0.74 | MAOA (1.00) | MAOACES1BCHEALDH1A1CYP1A2 | |
| Anthrone SCHEMBL18143 | 0.74 | MAOA (1.00) | MAOACES1BCHEALDH1A1CYP1A2 | |
| SCHEMBL2377273 | 0.73 | CDK8 (0.46) | PLK4DAPK3PIM1PDGFRALTK | |
| Anthrone SCHEMBL30922196 | 0.72 | MAOA (0.95) | MAOACES1BCHEALDH1A1CYP1A2 | |
| Anthrone SCHEMBL22574797 | 0.72 | MAOA (0.95) | MAOACES1BCHEALDH1A1CYP1A2 | |
| Anthraquinone SCHEMBL22026730 | 0.72 | MAOA (0.95) | MAOACES1BCHEALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262807-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |