Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29680840 | 0.93 | MEN1 (0.54) | SMN1; SMN2LMNAMAPTCYP3A4CYP2C19 | |
| SCHEMBL29681068 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAMAPTCYP3A4CYP2C19 | |
| SCHEMBL6978816 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAMAPTCYP2C19MEN1 | |
| SCHEMBL485392 | 0.83 | CYP11B2 (0.54) | CYP11B2SMN1; SMN2LMNAMAPTCYP3A4 | |
| SCHEMBL30769248 | 0.82 | CYP11B2 (0.55) | CYP11B2LMNAMAPTCYP3A4CYP2C19 | |
| SCHEMBL485607 | 0.82 | HDAC2 (0.58) | CYP11B2LMNAMAPTCYP3A4CYP2C19 | |
| SCHEMBL484886 | 0.82 | CYP11B2 (0.55) | CYP11B2SMN1; SMN2LMNAMAPTCYP3A4 | |
| SCHEMBL7366656 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAMAPTCYP2C19MEN1 | |
| SCHEMBL10316359 | 0.80 | GPR119 (0.69) | SMN1; SMN2LMNAMAPTCYP2C19MEN1 | |
| SCHEMBL485220 | 0.80 | CYP11B2 (0.53) | CYP11B2LMNAMAPTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133285-A1 | MOLECULES AND METHODS RELATED TO TREATMNET OF DISORDERS ASSOCIATED WITH JAK-2 SIGNALING DYSFUNCTION | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2022-06-23 | — | — | WO | disclosed |