Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.46 |
| ▸ | MTOR | P42345 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29681058 | 0.79 | ALDH1A1 (0.37) | KMT2AKDM4EPOLBALDH1A1MEN1 | |
| SCHEMBL24528584 | 0.79 | ALDH1A1 (0.37) | KMT2AKDM4EPOLBALDH1A1MEN1 | |
| SCHEMBL29680973 | 0.76 | KDM4E (0.41) | PIK3CAMTORKMT2AKDM4EHPGD | |
| SCHEMBL29680708 | 0.75 | GSK3B (0.41) | PIK3CAMTORKMT2AKDM4EHPGD | |
| SCHEMBL24528654 | 0.75 | ALDH1A1 (0.39) | KMT2AKDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL29681135 | 0.75 | ALDH1A1 (0.39) | KMT2AKDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL29680812 | 0.75 | GSK3B (0.40) | PIK3CAMTORKMT2AKDM4EHPGD | |
| SCHEMBL24528609 | 0.74 | XDH (0.44) | POLBALDH1A1TSHRMAPT | |
| SCHEMBL24528680 | 0.73 | ALDH1A1 (0.40) | KMT2AKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL29680625 | 0.72 | KDM4E (0.48) | PIK3CAMTORKMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4263539-A1 | 6-6 OR 5-6 FUSED BICYCLIC COMPOUNDS COMPRISING A PYRI(MI)DINE RING USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022129376-A1 | 6-6 OR 5-6 FUSED BICYCLIC COMPOUNDS COMPRISING A PYRI(MI)DINE RING USEFUL IN THE|TREATMENT OF INFECTIOUS DISEASES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2022-06-23 | — | — | WO | disclosed |