D-Glutamate

D-Glutamate

SCHEMBL29684232

N[C@H](CCC(=O)O)C(=O)[O-].N[C@H](CCC(=O)O)C(=O)[O-].[Ca+2]

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN2D known ✓ O15399 1/20 0.62
GRIN3B known ✓ O60391 1/20 0.62
GRIN1 known ✓ Q05586 1/20 0.62
GRIN2A known ✓ Q12879 1/20 0.62
GRIN2B known ✓ Q13224 1/20 0.62
GRIN2C known ✓ Q14957 1/20 0.62
GRIN3A known ✓ Q8TCU5 1/20 0.62
GABRP known ✓ O00591 2/20 0.50
GABRD known ✓ O14764 2/20 0.50
GABRA1 known ✓ P14867 2/20 0.50
GABRB1 known ✓ P18505 2/20 0.50
GABRG2 known ✓ P18507 2/20 0.50
GABRB3 known ✓ P28472 2/20 0.50
GABRA5 known ✓ P31644 2/20 0.50
GABRA3 known ✓ P34903 2/20 0.50
GABRA2 known ✓ P47869 2/20 0.50
GABRB2 known ✓ P47870 2/20 0.50
GABRA4 known ✓ P48169 2/20 0.50
GABRE known ✓ P78334 2/20 0.50
GABRA6 known ✓ Q16445 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D-Glutamate SCHEMBL587122 1.00 CYP1A2 (0.62) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL10341218 0.98 CYP1A2 (0.60) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL7695194 0.98 CYP1A2 (0.60) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL9243551 0.98 CYP1A2 (0.60) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL4383845 0.98 CYP1A2 (0.60) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL10930916 0.98 CYP1A2 (0.60) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL9650512 0.98 CYP1A2 (0.60) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL10930108 0.96 CYP1A2 (0.58) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL718336 0.95 CYP1A2 (0.62) CYP1A2GRM8GRM6GRIN2DGRIN3B
D-Glutamate SCHEMBL8746869 0.95 CYP1A2 (0.62) CYP1A2GRM8GRM6GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114705788-B Method for detecting smelly substances in water body 北京建筑大学 2022-08-19 CN claimed
CN-114705788-A Method for detecting smelly substances in water body 北京建筑大学 2022-07-05 CN claimed
CN-114705788-B Method for detecting smelly substances in water body 北京建筑大学 2022-08-19 CN disclosed
CN-114705788-B Method for detecting smelly substances in water body 北京建筑大学 2022-08-19 CN disclosed
CN-114705788-A Method for detecting smelly substances in water body 北京建筑大学 2022-07-05 CN disclosed
CN-114705788-A Method for detecting smelly substances in water body 北京建筑大学 2022-07-05 CN disclosed