Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.43 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 6/20 | 0.41 |
| ▸ | CDK8 | P49336 | 6/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31712882 | 0.86 | RET (0.44) | IP6K1IP6K3IP6K2MAPK14HPGDS | |
| SCHEMBL29685869 | 0.83 | IP6K1 (0.39) | IP6K1CCNCCDK8SMN1; SMN2 | |
| SCHEMBL26918319 | 0.83 | IP6K1 (0.39) | IP6K1CCNCCDK8SMN1; SMN2 | |
| SCHEMBL29875412 | 0.78 | MAPK1 (0.38) | MTORMET | |
| SCHEMBL30615043 | 0.75 | ROCK2 (0.42) | — | |
| SCHEMBL31712852 | 0.72 | IP6K1 (0.36) | IP6K1CCNCCDK8SMN1; SMN2 | |
| SCHEMBL31187932 | 0.72 | PTPN11 (0.49) | CCNCCDK8CREBBPMAPK14DYRK1B | |
| SCHEMBL31712866 | 0.70 | CNR2 (0.36) | HPGDSSMN1; SMN2 | |
| SCHEMBL19657529 | 0.68 | PLK1 (0.57) | IP6K1IP6K3IP6K2PLK1CCNC | |
| SCHEMBL29875709 | 0.68 | LCK (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251624-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | Amgen, Inc (US) | 2023-10-04 | — | — | EP | claimed |
| CN-116783191-A | Tricyclic carboxamide derivatives as PRMT5 inhibitors | 美国安进公司 | 2023-09-19 | — | — | CN | claimed |
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | claimed |
| CN-119855817-A | Heterocyclic alkynyl-substituted amide derivatives, preparation method and application thereof | 成都微芯药业有限公司 | 2025-04-18 | — | — | CN | disclosed |
| WO-2025026381-A1 | HETEROCYCLYLALKYNYL SUBSTITUTED AMIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 成都微芯药业有限公司 | 2025-02-06 | — | — | WO | disclosed |
| EP-4288435-A1 | TRICYCLIC-AMIDO-BICYCLIC PRMT5 INHIBITORS | Amgen Inc. (US) | 2023-12-13 | — | — | EP | disclosed |
| CN-117062816-A | Tricyclic-amide-bicyclic PRMT5 inhibitors | 美国安进公司 | 2023-11-14 | — | — | CN | disclosed |
| EP-4251624-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | Amgen, Inc (US) | 2023-10-04 | — | — | EP | disclosed |
| CN-116783191-A | Tricyclic carboxamide derivatives as PRMT5 inhibitors | 美国安进公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2022169948-A1 | TRICYCLIC-AMIDO-BICYCLIC PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-08-11 | — | — | WO | disclosed |
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |