Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PIR | O00625 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TGFB1 | P01137 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26918319 | 0.88 | IP6K1 (0.39) | IP6K1TSHRPDE5APDE4BCHEK2 | |
| SCHEMBL29685869 | 0.88 | IP6K1 (0.39) | IP6K1TSHRPDE5APDE4BCHEK2 | |
| SCHEMBL31712871 | 0.81 | NNMT (0.40) | IP6K1PDE5ACHEK2HTR1BNNMT | |
| SCHEMBL31712857 | 0.77 | TSHR (0.42) | IP6K1TSHRPDE5APDE4BCHEK2 | |
| SCHEMBL29106210 | 0.73 | IP6K1 (0.38) | IP6K1TSHRPDE5ACHEK2NNMT | |
| SCHEMBL24159171 | 0.73 | TSHR (0.47) | TSHRPIRSMN1; SMN2 | |
| SCHEMBL7867810 | 0.73 | TSHR (0.47) | TSHRPIRSMN1; SMN2 | |
| SCHEMBL30041840 | 0.73 | TSHR (0.47) | TSHRPIRSMN1; SMN2 | |
| SCHEMBL29685367 | 0.72 | IP6K1 (0.43) | IP6K1SMN1; SMN2CCNCCDK8 | |
| SCHEMBL31172009 | 0.71 | IP6K1 (0.36) | IP6K1TSHRPDE5ACHEK2HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251624-B1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC (US) | 2025-10-29 | — | — | EP | claimed |