Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22118978 | 0.86 | TSHR (0.48) | LMNAGAACYP1A2CYP2C19KDM4E | |
| SCHEMBL22121370 | 0.84 | KDM4E (0.44) | LMNAGAAKDM4EALDH1A1PKM | |
| SCHEMBL14097078 | 0.83 | LMNA (0.68) | LMNAGAAKDM4EALDH1A1PKM | |
| SCHEMBL20037188 | 0.81 | LMNA (0.66) | LMNAGAACYP1A2KDM4EALDH1A1 | |
| SCHEMBL6516159 | 0.79 | ALDH1A1 (0.47) | LMNAGAACYP1A2CYP2C19KDM4E | |
| SCHEMBL15931406 | 0.79 | LMNA (0.45) | LMNAGAACYP1A2CYP2C19KDM4E | |
| SCHEMBL710008 | 0.78 | MAPT (0.56) | LMNAGAAKDM4EALDH1A1PKM | |
| SCHEMBL2518853 | 0.77 | HCAR3 (0.45) | LMNAGAAKDM4EALDH1A1HTT | |
| SCHEMBL22151650 | 0.77 | KDM4E (0.41) | LMNAGAAKDM4EALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL8048126 | 0.76 | MAPT (0.55) | LMNAGAAKDM4EALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114585623-A | Bis [ N- ((5-carbamoyl) -1H-benzo [ d ] imidazol-2-yl) pyrazole-5-carboxamide ] derivatives and related compounds as STING (interferon gene stimulator) agonists for the treatment of cancer | 梅尔莎纳医疗公司 | 2022-06-03 | — | — | CN | disclosed |