Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | EIF4E | P06730 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20255018 | 1.00 | LMNA (0.46) | LMNAKDM4EHTTDHODHMKNK1 | |
| SCHEMBL29688594 | 0.81 | AKR1C3 (0.44) | MKNK1MKNK2CYP11B1CYP11B2ACLY | |
| SCHEMBL20243515 | 0.81 | AKR1C3 (0.44) | MKNK1MKNK2CYP11B1CYP11B2ACLY | |
| SCHEMBL29688422 | 0.78 | CYP11B1 (0.39) | KDM4EHTTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL30590299 | 0.78 | CYP11B1 (0.39) | KDM4EHTTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL20240859 | 0.78 | CYP11B1 (0.39) | KDM4EHTTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL29688628 | 0.77 | POLB (0.39) | KDM4EHTTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL30312124 | 0.76 | HTT (0.49) | LMNAKDM4EHTTDHODHMKNK1 | |
| SCHEMBL29688933 | 0.73 | KDM4E (0.41) | KDM4EHTTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL20254635 | 0.73 | KDM4E (0.41) | KDM4EHTTCYP11B1CYP11B2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110267959-B | Imidazo [1,5-A ] pyrazine derivatives as PI3K delta inhibitors | 百济神州有限公司 | 2022-05-27 | — | — | CN | disclosed |