Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 11/20 | 0.38 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18865627 | 1.00 | OPRL1 (0.38) | OPRL1LPLLIPGROCK2LIPE | |
| SCHEMBL18794974 | 0.75 | P2RX7 (0.30) | P2RX7 | |
| SCHEMBL29446647 | 0.75 | LPL (0.38) | LPLLIPGLIPEP2RX7 | |
| SCHEMBL971840 | 0.75 | LPL (0.38) | LPLLIPGLIPEP2RX7 | |
| SCHEMBL26674783 | 0.75 | PDE10A (0.37) | ROCK2 | |
| SCHEMBL22040325 | 0.75 | ROCK2 (0.41) | ROCK2LIPE | |
| SCHEMBL29513574 | 0.75 | ROCK2 (0.41) | ROCK2LIPE | |
| SCHEMBL26923229 | 0.75 | PDK2 (0.38) | — | |
| SCHEMBL16473312 | 0.73 | LPL (0.37) | LPLLIPGLIPE | |
| SCHEMBL2813914 | 0.73 | LPL (0.40) | LPLLIPGLIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024233665-A1 | COMPOUNDS AND THEIR USE AGAINST CANCER | TANGO THERAPEUTICS, INC. (US) | 2024-11-14 | — | — | WO | disclosed |
| EP-4308566-A1 | PURINE DERIVATIVES AS ANTICANCER AGENTS | Tango Therapeutics, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197892-A1 | PURINE DERIVATIVES AS ANTICANCER AGENTS | TANGO THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| CN-114702495-A | Purinones as ubiquitin-specific protease 1 inhibitors | 福马治疗有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-108473495-B | Purinones as ubiquitin-specific protease 1 inhibitors | 福马治疗有限公司 | 2022-04-12 | — | — | CN | disclosed |