Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24489089 | 1.00 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2HPGDF2KDM4E | |
| SCHEMBL12758444 | 0.89 | PDCD1 (0.58) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL3622343 | 0.83 | TSHR (0.63) | ALDH1A1SMN1; SMN2HPGDKDM4EKMT2A | |
| SCHEMBL29577973 | 0.82 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2HPGDKDM4EKMT2A | |
| SCHEMBL24489012 | 0.82 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2HPGDKDM4EKMT2A | |
| SCHEMBL12758441 | 0.74 | KMT2A (0.60) | ALDH1A1SMN1; SMN2HPGDKMT2ANPC1 | |
| SCHEMBL9283635 | 0.74 | NPC1 (0.63) | ALDH1A1SMN1; SMN2HPGDKDM4EKMT2A | |
| SCHEMBL21446806 | 0.74 | HDAC1 (0.59) | SMN1; SMN2KDM4ERAB9APDCD1CD274 | |
| SCHEMBL3618064 | 0.74 | NPC1 (0.60) | ALDH1A1SMN1; SMN2HPGDF2KDM4E | |
| SCHEMBL13545936 | 0.74 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2HPGDKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4008717-A2 | NOVEL INHIBITORS OF INSULIN-LIKE GROWTH FACTOR 2 MRNA BINDING PROTEINS | Martin-Luther-Universität Halle-Wittenberg (DE) | 2022-06-08 | — | — | EP | disclosed |