Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.40 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24568807 | 1.00 | AMY1A (0.40) | AMY1AAGPAT2TGFBR1HSP90AA1HSP90AB1 | |
| SCHEMBL24569028 | 0.85 | HSP90AA1 (0.40) | AMY1AAGPAT2TGFBR1HSP90AA1HSP90AB1 | |
| SCHEMBL24568805 | 0.82 | AGPAT2 (0.41) | AGPAT2TGFBR1HSP90AA1HSP90AB1ACVR1B | |
| SCHEMBL28994427 | 0.79 | TGFBR1 (0.46) | TGFBR1ACVR1BACVRL1PIM1 | |
| SCHEMBL30366114 | 0.77 | AMY1A (0.41) | AMY1ATGFBR1ACVR1B | |
| SCHEMBL24568403 | 0.76 | KDM4E (0.47) | TGFBR1ACVR1BACVRL1 | |
| SCHEMBL29694357 | 0.75 | S1PR4 (0.34) | AGPAT2TGFBR1ACVR1BACVRL1DPP4 | |
| SCHEMBL24568816 | 0.75 | S1PR4 (0.34) | AGPAT2TGFBR1ACVR1BACVRL1DPP4 | |
| SCHEMBL24568836 | 0.73 | ERN1 (0.46) | HTR2B | |
| SCHEMBL29694333 | 0.73 | ERN1 (0.46) | HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267584-A1 | PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136221-A1 | PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-30 | — | — | WO | disclosed |