Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24568079 | 0.85 | S1PR4 (0.43) | S1PR4NPBWR1MAPTMEN1KMT2A | |
| SCHEMBL30365733 | 0.80 | MAPT (0.42) | S1PR4MAPTMEN1KMT2AHTT | |
| SCHEMBL24568276 | 0.80 | MAPT (0.42) | S1PR4MAPTMEN1KMT2AHTT | |
| SCHEMBL24568807 | 0.77 | AMY1A (0.40) | AMY1AACVR1BTGFBR1 | |
| SCHEMBL29694366 | 0.77 | AMY1A (0.40) | AMY1AACVR1BTGFBR1 | |
| SCHEMBL28994437 | 0.75 | AMY1A (0.41) | AMY1AS1PR4NPBWR1MAPTMEN1 | |
| SCHEMBL30365942 | 0.72 | MAPT (0.40) | S1PR4MAPTMEN1KMT2AHTT | |
| SCHEMBL4002630 | 0.69 | GPR35 (0.36) | AMY1AMAPTMEN1KMT2AHTT | |
| SCHEMBL30365841 | 0.69 | GPR35 (0.36) | AMY1AMAPTMEN1KMT2AHTT | |
| SCHEMBL31166598 | 0.67 | GPR35 (0.38) | S1PR4MAPTMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4182323-B1 | PYRIDO OXAZINE AMINO DERIVATIVES AS ALK5 INHIBITORS | CHIESI FARM SPA (IT) | 2024-04-24 | — | — | EP | disclosed |
| EP-4182323-A1 | PYRIDO OXAZINE AMINO DERIVATIVES AS ALK5 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2023-05-24 | — | — | EP | disclosed |
| CN-116075307-A | Pyridooxazine amino derivatives as ALK5 inhibitors | 奇斯药制品公司 | 2023-05-05 | — | — | CN | disclosed |